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Description

This selective mechanism of action makes it more precise and safe in regulating growth hormone levels

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Superimposition of the ligand-free and GCG-bound GCGR structures reveals that five residues in the TM4, TM5 and ECL2 spatially clash with the cryo-EM density of chain X, including four phenylalanine (F278 4.56b , F289 4.67b , F303 ECL2 , and F309 5.41b ) and one isoleucine I306 5.38b (Supplementary Fig

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